Impassion030



impassion030 SVEN MAHNER Wenn Sie für Ihre Praxis/Klinik weitere Flyer Gesprächsabende benötigen, schreiben Sie uns eine Email: brustzentrum@med. Pre-clinically, cryo with checkpoint inhibition augmented tumor-specific immune responses and prevented recurrence. Studienzentrum im Onkozentrum Dresden Das ständige Bemühen um eine Verbesserung der therapeutischen Möglichkeiten in der Behandlung von Krebserkrankungen ist die Voraussetzung für eine exzellente Patientenversorgung. ALEXANDRA / IMpassion030 (BIG 16-05) Comparison of adjuvant anti PD-L1 antibody (atezolizumab) plus chemotherapy versus chemotherapy alone in TNBC patients. Map settings. Concretamente, la directora general y científica de GEICAM, Eva Carrasco, ha informado de que su organismo va a llevar a cabo el estudio ‘IMPassion030’ con atezolizumab en adyuvancia en pacientes con este tipo tumor. Contact Sauter la navigation. Adapt Cycle. alexandra/impassion030. Diablo Valley Oncology and Hematology Medical Group. Con este espíritu nace esta actividad formativa, Conclusiones GEICAM del SABCS, en IMPassion030: Status: Patienten können teilnehmen (offen) Erkrankung Brustkrebs, nicht metastasiert; Kurzbeschreibung: Eine multizentrische, randomisierte, offene IMpassion030-FASE III, Un estudio que compara el atezolizumab (anticuerpo anti PD-L1) en combinación con quimioterapia adyuvante a base de antraciclina / taxano versus quimioterapia sola en pacientes con cáncer de mama triple negativo operable 中外製薬は、HER2陽性早期乳癌に対する術前療法として、トラスツズマブ、ペルツズマブとアテゾリズマブの併用投与の有効性と安全性を評価する Impassion030/ Alexandra: Triple negativer Brustkrebs. global alexandra/impassion030 . Enable clustering for high density markers Label each marker Calculate (straight line) distance from first address ABCSG 47 / IMpassion030 Details * ABCSG Austrian Breast & Colorectal Cancer Study Group. Aug 10, 2020 Contributor By : James Michener Ltd PDF ID e55bcfce chemotherapy in psychiatry revised and enlarged edition pdf Favorite eBook Reading and expanded edition of a widely used book ross baldessarini chemotherapy in psychiatry revised and San Pathologic response to neoadjuvant chemotherapy: _ Improved outcome in TNBC Pathologic complete response (pCR) 20 HR a 018-033) Time since rarxlomisation (years) Programmed death-1/programmed death-ligand 1 inhibitors are emerging as novel treatments for triple-negative breast cancer. Oct 16, 2020 · 1. Pleasant Hill, CA 94523 (925) 677-5041 Methods: ALEXANDRA/IMpassion030 is a global, prospective, randomised, open-label Phase 3 trial investigating the efficacy, safety and pharmacokinetic (PK) profile of adjuvant atezolizumab plus standard chemotherapy versus chemotherapy alone in early TNBC. 1 Studies Multidisciplinary Breast Centre (MBC) Surgery Study S-number Indication Contact person LORD S60185 Aug 31, 2020 Contributor By : Dr. Contessa Trio. J Clin Oncol. Compared to other breast cancer subtypes, triple-negative breast cancer is characterized by a higher McArthur HL, Ignatiadis M, Guillaume S, et al. Halbjahr 2020 现如今,Giuliano博士仍在进行前哨淋巴结研究,他的一项长达10年的临床研究表明,对于部分早期乳腺癌患者,接受乳房肿瘤切除时,仅做小范围淋巴活检就足够了,不会影响生存率,该研究结果已发表在了《美国医学会杂… COVID-19 studies are our top priority. Apr 25, 2020 · 3 • Summarize the mechanisms of action of available and emerging therapies for TNBC within the context of the underlying tumor biology • Identify the role of new and emerging therapies in the treatment of TNBC MINIREVIEW Open Access Recent advances in triple negative breast cancer: the immunotherapy era Antonio Marra1,2, Giulia Viale1,2 and Giuseppe Curigliano1,2* Abstract Background: Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over IMpassion030 Etude de phase III, multicentrique, randomisée, en ouvert, comparant l'Atézolizumab (anticorps anti-pd-l1) en association à la chimiothérapie adjuvante à base d'anthracycline/taxane versus chimiothérapie seule chez des patients atteints d'un cancer du sein triple négatif opérable Oct 20, 2018 · Those listening closely on Roche’s quarterly call last week might have guessed that results from the Impassion-130 study in triple-negative breast cancer were not as strong as had been hoped. APTneo. Sep 24, 2018 · impassion030 (operable triple-negative breast cancer) People with breast cancer are asked to participate in a research study being conducted by Northwell Health. ALEXANDRA / IMpassion030 (BIG 16-05) A phase III, multicenter, randomised, open-label study comparing atezolizumab (anti PD-L1 antibody) in combination with adjuvant anthracycline/taxane-based chemotherapy versus chemotherapy alone in patients with operable triple negative breast cancer (TNBC). Sep 20, 2019 · Breast cancer is one of the three most common cancers diagnosed in women, and accounts for 30% of new cancer cases in women in the United States. a phase iii, multicenter, randomized, open-label study comparing atezolizumab (anti-pd Information for Providers. ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early stage triple-negative breast cancer. Clinically, subtypes are currently defined either by immunohistochemistry for hormone receptor and HER2 status, 1,2 or by high-throughput diagnostic technology such as gene expression arrays or next-generation sequencing. now recruiting. Infine, in Italia sono in corso nel setting adiuvante lo studio IMpassion030 (studio clinico di fase III, in aperto, di confronto tra atezolizumab in combinazione con chemioterapia adiuvante Für Einbringung offene Studien Laufend, aber für Einbringung geschlossen Suchhilfe. Oct 16, 2020 · Adjuvant therapy: Immuno + chemotherapy (IMpassion030) Pac +/− atezolizumab, followed by dose-dense AC or EC alone: Stage II-III operable: Recruiting: 2,300: 8/2/2018; 1/15/2022: NCT03498716: Immuno + chemotherapy (IMpassion130) Nab-pac +/− atezolizumab: Previously untreated locally advanced or metastatic: Active, not recruiting: 900: 6/23 IMpassion030 Etude de phase III, multicentrique, randomisée, en ouvert, comparant l'Atézolizumab (anticorps anti-pd-l1) en association à la chimiothérapie adjuvante à base d'anthracycline/taxane versus chimiothérapie seule chez des patients atteints d'un cancer du sein triple négatif opérable She has designed, conducted, and reported on many studies in breast cancer and is currently the co-PI for a large, randomized, international phase 3 study exploring adjuvant chemotherapy with or without immune therapy for the treatment of triple negative breast cancer (IMpassion030). Clinically, we established that peri-operative (peri-op) cryo with ipilimumab (ipi) +/- nivolumab (nivo) was not only safe in patients ABCSG 47 / Impassion030 / ALEXANDRA Details ABCSG 49 / POLAR Eine unverblindete, multizentrische, randomisierte Studie der Phase III zu adjuvantem Palbociclib in Kombination mit Endokriner Therapie versus Endokrine Therapie allein für Patienten mit Hormonrezeptor-positivem / HER2-negativem, isoliertem, lokoregionärem Brustkrebs-Rezidiv nach En el tratamiento del cáncer de mama los avances son continuados. Radiothérapie GANEA 3 *仅供医学专业人士阅读参考. If update date in update history is before 2018/12/15, the information was created in accordance with the old format. Ф. 全球 每100个新确诊的乳癌病例中,有12个来自中国,新发病率增长速度是世界平均水平的2倍,平均发病年龄比西方国家早10-15年 [1]。 Studien 6 bis 10 von 1452 - Den Überblick über die wichtigsten Studien behalten mit www. IMpassion030—WO39391 Etude de phase III, multicentrique, randomisée, en ouvert, comparant l’ATEZOLIZUMAB en association à une chimiothérapie à base d’anthracycline/Taxane versus une chimiothérapie seule chez des patients atteints d’un cancer du sein triple négatif opérable. 6 июля в России стартовало исследование III фазы компании Hoffmann-La Roche, Indiquez l'étude et le centre concernés : choisissez "Nouvelle étude" si vous désirez indiquer une étude non référencée. Wir dokumentieren Tumorpatientendaten vor Ort für Studien, NIS, AWB’s, ONkeyLINE und Qualitätssicherungsmaßnahmen in der Onkologie. She serves on study numerous steering committees and is currently the co-PI for a large, randomized, international effort exploring adjuvant chemotherapy with or without immune therapy for the treatment of triple breast cancer (Impassion030). DD adjuvant CT improves disease free survival (DFS) and overall survival (OS) in high-risk, hormone receptor positive BC. 0. ・ALEXANDRA/IMpassion030: 手術可能なトリプルネガティブ乳癌患者を対象とした、術後補助療法におけるアテゾリズマブ(抗 PD-L1抗体)+ アンスラサイクリン/タキサンベースの化学療法と化学療法単独を比較する多施設共同ランダム化非盲検第III 相試験 Retrouvez ici les essais cliniques menés par l'Institut Bergonié, le Centre de Lutte Contre le Cancer de la région Nouvelle-Aquitaine. . 免疫疗法为早期TNBC带来了希望,早期TNBC不论PD-L1表达状态如何,均可从免疫治疗中获益。期待未来有更多的阳性结果公布,为早期TNBC患者带来更多福音! 参考文献:(向上滑动阅览) 1. gov Relevante vurderingselementer for en metodevurdering Klinisk effekt relativt til komparator ☒ Nytt behandlingsprinsipp Sikkerhet ☒relativt til komparator Ny bivirkningsprofil Kostnader/ressursbruk ☒ 徐兵河 主任医师,教授,博士生导师. Oct 22, 2018 · IMpassion030 would recruit 2300 patients with stage 2 or 3 TNBC. Luminal A and luminal B subtypes have different sensitivity to (neo)adjuvant chemotherapy; however, their role in predicting DD efficacy in clinically high-risk setting is uncertain. IBCSG 56-17 IMpassion030 / ALEXANDRA IBCSG 55-17 TOUCH IBCSG 54-16 METEORA-II IBCSG 51-14 AURORA International Breast Cancer Study Group Effingerstrasse 40 ABCSG 45 . Silver Linings Gleaned from COVID-19. T Goulioti's 25 research works with 1,040 citations and 3,329 reads, including: Lucitanib for the treatment of HR + / HER2 - metastatic breast cancer: results from the multicohort phase II FINESSE PDF | Background Up to now, preoperative and postoperative chemotherapies are mainly based on anthracycline and taxane for early breast cancer, however, | Find, read and cite all the research (IMpassion030): A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti-PD-L1) Antibody in Combination with Adjuvant Anthracycline/Taxane IMpassion030 A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane Jul 02, 2020 · There are many ongoing trials investigating PD-L1 inhibition in TNBC including studies examining atezolizumab [IMpassion030 (NCT03498716), IMpassion031 (NCT03197935), IMpassion131 (NCT03125902) and IMpassion132 (NCT03371017)], avelumab [A-Brave (NCT02926196) and InCITe (NCT03971409)] and durvalumab [DORA (NCT03167619) and PANDoRA (NCT03872505)]. 结语. 2007 Triple Negative Breast Cancer (TNBC): high unmet medical need IMpassion030 III A phase 3, multicenter, randomized, open-label study comparing atezolizumab (anti-PD-L1-antibody) in combination with standard adjuvant ALEXANDRA/IMpassion030 (GBG 98, BIG 16-05, AFT-27), NCT03498716: trial in progress #OT3-05-02 ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early triple negative breast cancer. 乳腺癌是女性非常常见的癌症,全球每年大约有200多万新发病例。 根据美国癌症协会(acs),2020年美国大约会有28万新发侵袭性乳腺癌病例,死亡病例超过4. Г. Alliance Foundation Trials, LLC (AFT) Alliance Foundation Trials, LLC (AFT) is a research organization that develops and conducts cancer clinical trials, working closely with the Alliance for Clinical Trials in Oncology scientific investigators and institutional member network, research collaborators, and non-NCI funding sources. Several biomarkers including estrogen receptor α (ERα), progesterone receptor (PR), and human epidermal growth factor receptor-2 (ERBB2/HER2) have been established, and the main breast cancer subtypes are classified according to their molecular profile (1,2). McArthur: There are a number of studies that are ongoing in that setting. IMpassion030 תיאור המחקר: אטזוליזומאב בשילוב כימותרפיה מול כימותרפיה בלבד קו טיפולי: טיפול משלים לניתוח (אדג'ובנטי) למטופלות TNBC תנאי כניסה עיקריים: Додаток 1 до наказу Міністерства охорони. Sampling of ALEXANDRA/IMpassion030. Background. IMpassion030 A Study to Compare Atezolizumab (Anti-PD-L1 Antibody) in Combination with Adjuvant Anthracycline/Taxane based Chemotherapy Versus Chemotherapy Alone in Patients with Operable Triple-Negative Breast Cancer (Aktiv) Atezolizumab F. Mehr < 1 2 3 4 5 > Currently, he is the study chair of the Alexandra/Impassion030 registration trial and the NeoRhea trial. The concept of precision medicine has been around for many years and recent advances in high-throughput sequencing techniques are enabling this to become reality. Within the field of breast cancer, a number of signatures have been developed to molecularly sub-classify tumours. Apr 25, 2020 · Current trials comparing neoadjuvant chemoimmunotherapy with chemotherapy alone include CheckMate 816, KEYNOTE-671, and IMpassion030. ALEXANDRA/IMpassion030: a phase III study of standard adjuvant chemotherapy with or without atezolizumab in early-stage triple-negative breast cancer. 中国医学科学院、北京协和医学院肿瘤医院内科主任 中国抗癌协会乳腺癌专业委员会第七届主任委员 中国抗癌协会肿瘤药物临床研究专业委员会候任主任委员 国家肿瘤质控中心乳腺癌专家委员会主任委员 中国老年医学学会肿瘤分会副会长 北京乳腺病防治学会 DS-8201a Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04] IMpassion030 # of patients N=324 N=2,300 ARM A: Tecentriq plus nab-paclitaxel ARM A: Tecentriq + paclitaxel followed by AC followed by Tecentriq ARM B: Placebo plus nab-paclitaxel + AC, followed by Tecentriq maintenance 6月18日,罗氏宣布阿替利珠单抗联合化疗用于早期三阴性乳腺癌(TNBC)的III期IMpassion031研究到达病理学完全缓解(pCR)的主要终点,无论PD-L1状态如何。 1 Übersicht Klinische Studien Klinische Abteilung für Onkologie. ABCSG Austrian Breast & Colorectal Cancer Study Group. DR. A phase II, single arm study assessing the ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early-stage triple-negative breast cancer. 2019 ASCO Annual Meeting - 6/1/2019 A phase II, single arm study assessing the efficacy of pembrolizumab (Pembro) plus radiotherapy (RT) in metastatic triple negative breast cancer (mTNBC). de. at. National Comprehensive Cancer ロシュ社は本日、テセントリク ® (アテゾリズマブ)の第III相臨床試験であるIMpassion130試験において、本試験の二つの主要評価項目の一つである無増悪生存期間(PFS)の延長が認められたことを発表しました。 6月18日,罗氏宣布阿替利珠单抗联合化疗用于早期三阴性乳腺癌(TNBC)的III期IMpassion031研究到达病理学完全缓解(pCR)的主要终点,无论PD-L1状态如何。 徐兵河 主任医师,教授,博士生导师. His work in the field of blood-based biomarkers is widely recognized at the international level. 10. "Breast cancer weakly stimulates the immune system. Tumorgröße > 2cm: Untersuchung der Wirksamkeit und Sicherheit von Atezolizumab (Anti-PD-L1-Antikörper) in Kombination mit einer adjuvanten Anthracyclin / Paclitaxel-basierten Chemotherapie im Vergleich zu Placebo und Chemotherapie bei Patienten mit primärem invasivem triple negativem IMpassion030: A phase III, multicenter, randomized, open-label study comparing Atezolizumab (ANTI-PD-L1 antibody) in combination with adjuvant anthracycline/taxane IMPassion030: Status: Patienten können teilnehmen (offen) Erkrankung Brustkrebs, nicht metastasiert; Kurzbeschreibung: Eine multizentrische, randomisierte, offene IMpassion030 Etude de phase III, multicentrique, randomisée, en ouvert, comparant l'Atézolizumab (anticorps anti-pd-l1) en association à la chimiothérapie adjuvante à base d'anthracycline/taxane versus chimiothérapie seule chez des patients atteints d'un cancer du sein triple négatif opérable IMPASSION030 (GBG 98) Diese klinische Studie untersucht die Anwendung von Atezolizumab (Anti PD-L1 Antiköper) in Kombination mit adjuvanter Anthrazyklin/Taxan haltiger Chemotherapie versus Chemotherapie alleine bei Patienten mit operablem triple negativem Brustkrebs. Our compassionate medical staff is committed to providing high quality healthcare services in the West Coast and Hawaii. Name No. Oct 22, 2018 · IMpassion030 (Ph III Adj) KATHERINE (Ph III non-pCR Adj) IMpassion132 (Ph III 1L) IMpassion050 (Ph III NeoAdj) Entrectinib (pan-TRK/ROS1 inhibitor) fits our PHC strategy Researchers eagerly await results from several clinical trials testing immunotherapies in metastatic breast cancer, including A-BRAVE, IMpassion030, and NeoTRIPaPDL1 (Table). A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Nonsteroidal Aromatase Inhibitors (Anastrozole or Letrozole) Plus LY2835219, a CDK4/6 Inhibitor, or Placebo in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative Locoregionally Recurrent or Metastatic Breast Cancer With No Prior Systemic Therapy in This Disease Setting TNBC (IMpassion030) 03498716 TNBC 2300 December 2024 Hoffmann-La Roche 3 Pembrolizumab Paclitaxel Doxorubicin Epirubicin Cyclophosphamide Study of pembrolizumab (MK-3475) vs Placebo in combination with neoadjuvant chemotherapy & adjuvant endocrine therapy in the treatment of early-stage ER-Positive, HER2-Negative 進行トリプルネガティブ乳がん(TNBC)への1次治療として、nab-パクリタキセルと抗PD-L1抗体アテゾリズマブの併用療法が、無増悪生存期間(PFS)を有意に改善した。日本も参加している第III相ランダム化比較試験IMpassion130の結果に基づき、英国・ロンドン大学クイーン・メアリー校のPeter Schmid氏 Sehen Sie sich das Profil von Jorge Martinez im größten Business-Netzwerk der Welt an. Currently, he is the study chair of the Alexandra/Impassion030 registration trial and the NeoRhea trial. Яновського Національної академії медичних наук України», відділення діагностики, терапії та клінічної фармакології захворювань легень, м. Medizinische Universität Wien. Mittendorf, MD, PhD, Jennifer Litton, MD, and Heather L. Session: Poster Session OT3–Friday, December 7, 5:00 pm – 7:00 pm (poster) a Developed in collaboration with Array BioPharma. We're conducting a range of breast cancer clinical trials. clinicaltrials. Tamendox. uni-muenchen. Oct 01, 2019 · ALEXANDRA/IMpassion030 is a global, prospective, randomized, open-label, phase 3 trial currently investigating the efficacy, safety and pharmacokinetic profile of adjuvant atezolizumab plus standard anthracycline/taxane adjuvant chemotherapy versus chemotherapy alone in early stage TNBC. Sauter la navigation. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Jorge Martinez und Jobs bei ähnlichen Unternehmen erfahren. 0 0 0 ご訪問ありがとうございます。新年早々の予定外の骨折・通院もあり (原因は癌とは無関係です)仕事上の資料まとめもあり元々tvは、ほとんど見ないのもあり見てみよ… New opportunity 15% TNBC IMpassion130 (Ph III 1L), filed IMpassion131 (Ph III 1L) Roche marketed 20% IMpassion132 (Ph III 1L) Her2+ IMpassion031 (Ph III NeoAdj) IMpassion030 (Ph III Adj) KATHERINE (Ph III non-pCR Adj) UMIN Clinical Trials Registry(UMIN-CTR)は、ICMJEの基準を満たす登録サイトとして正式に認められております。 Entrez votre recherche et validez avec Entrée. Étude de phase III, multicentrique, randomisée, en ouvert, comparant l'atézolizumab (Anticorps Anti-PD-L1) en association à la chimiothérapie adjuvante à base d'anthracycline/taxane versus chimiothérapie seule chez des patients atteins d'un cancer du sein triple négatif opérable » Etude IMPASSION030 - Protocole WO39391 图5 IMpassion030试验与NSABP B-59试验的研究设计. Informationen für Bewerber. The complexity behind the treatment of breast cancer arises, in part, from the presence of biologically distinct subtypes. MED. There's also the ALEXANDRA or IMpassion030 study. La formación médica es fundamental para actualizar los conocimientos, avanzar en más opciones terapéuticas y conseguir un tratamiento individualizado para cada paciente. Nous connaître. Jan 15, 2020 · ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early-stage triple-negative breast cancer. txt) or read book online for free. Notre centre; Notre histoire; Nos atouts; Nos engagements; Nos instances budosy Doku-Service und Systemberatung: Clinical Research Associate. Atezolizumab, Pertuzumab und Trastuzumab mit Local tumor destruction with cryoablation (cryo) induces inflammation and releases antigens that can activate tumor-specific immune responses. pdf), Text File (. 0 0 0 100. de המחקרים המפורטים מטה, הם אלו הפתוחים לגיוס משתתפים בלבד, ואינם כוללים את המחקרים שעדיין פעילים אך נסגרו לגיוס חולים. 18‐1‐2020 1 Studies Multidisciplinary Breast Centre (MBC) Surgery Study S‐number Indication Contact person LORD S60185 Management of low grade ductal carcinoma in situ (low‐grade DCIS): a randomized, CLOSED OPEN Data Title ORTHOPEDICS GENERAL SURGERY NEUROLOGY Condition(s) atrial fibrillation ischemic stroke breast cancer recruiting Start Date brain metastases Jan 07, 2020 · 1-7-2020 . This study will evaluate the efficacy, safety, and pharmacokinetics of adjuvant atezolizumab in combination with paclitaxel Apr 24, 2015 · This multicenter, randomized, double-blind study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab (MPDL3280A) administered with nab-paclitaxel compared with placebo in combination with nab-paclitaxel in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic breast cancer (mBC). journalonko. a Dent et al. b Ignyta, Inc acquisition. Im Profil von Jorge Martinez sind 10 Jobs angegeben. Given the success of this trial, atezolizumab is currently being studied in a variety of other settings in combination with chemotherapy, including the neoadjuvant (IMpassion031), adjuvant (IMpassion030), and recurrent TNBC (IMpassion132), among others. The ANSM reminds that the management of COVID-19 patients in France must be carried out in accordance with the recommendations of the Haut Conseil de Santé Publique (High Council of Public Health), available at Haut Conseil de Santé Publique - "Le point sur le Coronavirus" and according to the recommendations of the Scientific Council COVID-19 available on the website of the Ministry of Health. מחקר שלב iii להערכת מתן אָטֶזוֹליזוּמָאבּ (טיסֶנְטְרִיק, נוגדן נגד pd-l1) בשילוב עם כימותרפיה IMpassion030 Cáncer de mama. McArthur, MD, MPH, prepared useful Practice Aids pertaining to triple-negative breast cancer for this CME/MOC/CNE activity titled, "On the Cusp of the Era of Immuno-Oncology in Triple-Negative Breast Cancer: Rational Strategies to Make the Most of Immunotherapies and Other Effective Treatment Modalities Throughout the Concretamente, la directora general y científica de GEICAM, Eva Carrasco, ha informado de que su organismo va a llevar a cabo el estudio 'IMPassion030' con atezolizumab en adyuvancia en pacientes Державна установа «Національний інститут фтизіатрії і пульмонології ім. Drug Name Trade Name Synonyms Drug Classes Drug Description; Cyclophosphamide Cytoxan: CPM: Chemotherapy - Alkylating 14 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). 15_suppl): Abstract TPS598. Impassion030 ATEZOLIZUMAB (Anti PD-L1 Antiköper) in Kombination mit adjuvanter Anthrazyklin/Taxan haltiger Chemotherapie versus Chemotherapie alleine bei Patienten mit operablem triple negativem Brustkrebs. A prospective, open, randomized, phase II study of carboplatin/ olaparib in the pre-operative treatment of patients with triple-negative primary breast cancer which exhibit the features of positive homologous recombination deficiency (HRD) status McArthur HL, Ignatiadis M, Guillaume S, et al. 2万。 Impassion030. Introduction. For Early-Stage Breast Cancer, Advanced Breast Cancer, and all patients undergoing breast surgery at St Vincent’s Hospital Sydney. /adj. здоров’я України. d Developed in collaboration with Exelixis. 1. IMpassion030 Program Estudio de fase III, multicéntrico, aleatorizado y abierto para comparar atezolizumab (anticuerpo anti-PD-L1) en combinación con quimioterapia adyuvante basada en antraciclina/taxano frente a solo quimioterapia en pacientes con cáncer de mama triple negativo operable. Nov 15, 2018 · n engl j med 379;22 nejm. For Patients with Purpose; ALEXANDRA/IMpassion030: 17-15 (WO39391 / BIG 16-05) Early stage breast cancer. Everolimus in Subjects with Advanced or Metastatic Clear-Cell - die IMPassion030-Studie. 2019 № 2107 Назва клінічного випробування, код, версія та дата «Оцінка препарату рекомбінантного фактора ix, apvo101, у дітей, хворих на гемофілію В, яким раніше Jun 06, 2019 · Elizabeth A. 400 Taylor Blvd. Cáncer de mama: Un estudio que compara al Atezolizumab (Anticuerpo anti PD-L1) en combinación con quimioterapia adyuvante basada en antraciclina/ taxano contra quimioterapia sola en pacientes con cáncer de mama triple negativo operable IMpassion030-FASE III, Un estudio que compara el atezolizumab (anticuerpo anti PD-L1) en combinación con quimioterapia adyuvante a base de antraciclina / taxano versus quimioterapia sola en pacientes con cáncer de mama triple negativo operable 0 0 0. Atezolizumab (atezo; MPDL3280A), a humanized anti-PDL1 antibody, inhibits PD-L1 binding to PD-1 and B7. 57)发表了篇三阴乳腺癌的综述,详细介绍了免疫检查点抑制剂(ICIs)单药以及联合化疗、靶向和新型免疫疗法的联合策略,展现了三阴乳腺癌免疫抑制剂治疗的一个框架,方便大家理解免疫抑制剂在三阴乳腺癌的现有临床经验和正在进行的研究现状。 ABCSG 47 / Impassion030 Übersicht. We summarize the results of recent c Tecentriq clinical trial estimate: Primary completion of P3 IMpassion030 trial (NCT03498716) for TNBC on January 15, 2022 (Barclays) – Aug 9, 2019 – A subscription to Thomson ONE is required to gain full access to report 67703402; Page no: 1; REPORT TITLE: “Roche Holding Ltd: ROG: (neo)adjuvant TNBC: Beaten to the punch…”; AUTHOR IMpassion030 Program Estudio de fase III, multicéntrico, aleatorizado y abierto para comparar atezolizumab (anticuerpo anti-PD-L1) en combinación con quimioterapia adyuvante basada en antraciclina/taxano frente a solo quimioterapia en pacientes con cáncer de mama triple negativo operable. -031 zur Evaluierung einer potenziellen (neo)adjuvanten Ausweitung der Verwendung der Kombination von Atezolizumab und nab-Paclitaxel beim TNBC. Le Pôle Régional. The AEGEAN study is comparing the anti–PD-L1 agent durvalu­mab with placebo; Other trials are employing novel designs and incorporating novel agents. gov Identifier www. В начале июня Чикаго прошла очередная ежегодная конференция ASCO, на которой один из докладчиков, доктор Gilberto Lopes (на снимке) из Sylvester Comprehensive Cancer Center в Майами рассказал о результатах большого исследования, которые могут Impassion030. Zudem laufen die Studien IMpassion030 bzw. Breast cancer is characterized by heterogeneity at the molecular and clinical levels. Impassion030/ Alexandra: Triple negativer Brustkrebs. We anticipate taking learnings and new ways of working, developed out of critical need, into the post-pandemic world — from engaging in partnerships and advancing clinical trials to leveraging virtual technology. After the latest news, I fear a run on slots! Which is concerning Ongoing randomized Phase III clinical trials evaluating anti-PD-1/PD-L1 antibodies with chemotherapy for patients with localized TNBC (eg, IMpassion030, SWOG-S1418) MODULE 3: Current and Future Role of PARP Inhibitors for Patients with TNBC and a BRCA Mutation Background. orgNovember 29, 2018 2109 Atezolizumab and Nab-Paclitaxel in Breast Cancer T riple-negative breast cancer is the term used to describe breast cancers that Ongoing randomized Phase III clinical trials evaluating anti-PD-1/PD-L1 antibodies with chemotherapy for patients with localized TNBC (eg, IMpassion030, SWOG-S1418) MODULE 3: Current and Future Role of PARP Inhibitors for Patients with TNBC and a BRCA Mutation Sep 16, 2019 · • IMpassion030: adjuvant TNBC • IMpassion031: neoadjuvant TNBC • GEPARDOUZE: neoadj. Ongoing randomized Phase III clinical trials evaluating anti-PD-1/PD-L1 antibodies with chemotherapy for patients with localized TNBC (eg, IMpassion030, SWOG-S1418) MODULE 3: Current and Future Role of PARP Inhibitors for Patients with TNBC and a BRCA Mutation Drug Name Trade Name Synonyms Drug Classes Drug Description; Cyclophosphamide Cytoxan: CPM: Chemotherapy - Alkylating 14 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Gepar Douze. 2019;37(no. IBCSG 56-17 IMpassion030 / ALEXANDRA This is a global Phase III, open-label, randomized, controlled alexandra/impassion030; alexandra/impassion030. There's a study, the SWOG 1418 study, which is a study of a year of pembrolizumab after surgery for patients who have residual triple-negative breast cancer after neoadjuvant therapy. 2019;37(15 suppl): Abstract TPS598. ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early-stage triple-negative breast cancer. Suite 202. 1 receptors, thereby restoring tumor-specific immunity. Data of several GBG studies was presented at the upcoming ESMO Virtual Meeting 2020, which took place from 19 to 21 September 2020. IMpassion030 A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane "Con inmunoterapia, vamos a trabajar también con otros grupos internacionales como GEICAM, en enfermedad triple negativa en fases iniciales; será el 'IMpassion030' con Atezolizumab en adyuvancia Concretamente, la directora general y científica de GEICAM, Eva Carrasco, ha informado de que su organismo va a llevar a cabo el estudio 'IMPassion030' con atezolizumab en adyuvancia en pacientes IMpassion030 תיאור המחקר: אטזוליזומאב בשילוב כימותרפיה מול כימותרפיה בלבד קו טיפולי: טיפול משלים לניתוח (אדג'ובנטי) למטופלות TNBC תנאי כניסה עיקריים: ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early stage triple negative breast cancer Annals of Oncology Oct 2019 See publication MONARCH 3. B. IBCSG 56-17 IMpassion030 / ALEXANDRA Open Trials Closed Trials. 中外製薬は、HER2陽性早期乳癌に対する術前療法として、トラスツズマブ、ペルツズマブとアテゾリズマブの併用投与の有効性と安全性を評価する Eine Randomisierte open-Label Phase II Studie zur Untersuchung der Wirksamkeit und Sicherheit von Atezolizumab in Kombination with FLOT versus FLOT bei Patienten mit Magenkarzinom und Adenokarzinom des ösophagogastralen Überganges. Multizentrische, randomisierte, offene Phase-III-Studie zum Vergleich von Atezolizumab (Antikörper gegen PD-L1) in Kombination mit einer adjuvanten Anthracylin-/ Taxan-Chemotherapie gegenüber alleiniger Chemotherapie bei Patienten mit operablem dreifach negativem Brustkrebs GEICAM/2017-06 IMpassion030 lunes 17 octubre 2016 Fase III, quimioterapia adyuvante estándar basada en antraciclinas y taxanos +/- Atezolizumab en pacientes con CMTN operable, sin neoadyuvancia previa IMpassion030. About this trial. e Developed in collaboration with Chugai. IMpassion130 was a phase III trial that demonstrated progression-free survival benefit, and potentially overall survival benefit, of first-line IMpassion030 # of patients N=324 N=2,300 ARM A: Tecentriq plus nab-paclitaxel ARM A: Tecentriq + paclitaxel followed by AC followed by Tecentriq ARM B: Placebo plus nab-paclitaxel + AC, followed by Tecentriq maintenance Patients with advanced triple-negative breast cancer (TNBC) should avoid taking the therapy drug Tecentriq with paclitaxel. -031 zur Evaluierung einer potentiellen (neo)adjuvanten Ausweitung der Verwendung der Kombination von Atezolizumab und nab-Paclitaxel beim TNBC. Methods: ALEXANDRA/IMpassion030 is a global, prospective, randomized, open-label, phase 3 trial investigating the efficacy, safety and pharmacokinetic profile of adjuvant atezolizumab plus standard chemotherapy versus chemotherapy alone in early TNBC. Bitte wählen Sie sie Kategorie "ALLE" und geben Sie im Suchfeld eines oder mehrere der Schlagwörter ein, welche sich im Titel der Studie (z. Sempre nel nostro paese, si stano svolgendo altri due studi: uno (IMpassion030) confronta atezolizumab in combinazione con chemioterapia adiuvante rispetto alla sola chemioterapia (basata su antraciclina/taxano); l'altro (NeoTrip) confrontata in terapia neoadiuvante l’associazione atezolizumab, nab-paclitaxel e carboplatino verso nab ALEXANDRA/ WO39391/ IMpassion030: Estudio Fase III, multicéntrico, aleatorizado y abierto para comparar atezolizumab (Anticuerpo ANTI?PD-L1) en combinación con quimioterapia adyuvante basada en antraciclina/taxano frente a solo quimioterapia en pacientes con cáncer de mama triple negativo operable” If update date in update history is before 2018/12/15, the information was created in accordance with the old format. Tumorgröße > 2cm: Untersuchung der Wirksamkeit und Sicherheit von Atezolizumab (Anti-PD-L1-Antikörper) in Kombination mit einer adjuvanten Anthracyclin / Paclitaxel-basierten Chemotherapie im Vergleich zu Placebo und Chemotherapie bei Patienten mit primärem invasivem triple negativem Zumindest im metastasierten Setting ist dies wohl der Fall, und die präsentierten Daten stellen hier wohl einen Wechsel in der Standardbehandlung dar. Présentation du Pôle Régional de Cancérologie; Les missions du Pôle Régional de Cancérologie Ya se ha empezado a estudiar la inmunoterapia en el cáncer de mama triple negativo inicial, si bien todavía no hay datos. Prostata) wiederfinden. Beschreibung: Multizentrische, randomisierte, offene Phase-III-Studie zum Vergleich von Atezolizumab (Antikörper gegen PD-L1) in Kombination mit einer adjuvanten Anthracyclin-/ Taxan-Chemotherapie mit alleiniger Chemotherapie bei Patienten mit operablem dreifach-negativem Brustkrebs. This study will evaluate the efficacy, safety, and pharmacokinetics of adjuvant atezolizumab. Hoffmann-La Roche Ltd 2/Protocol BIG 16-05/AFT-27/WO39391, Version 3 PROTOCOL AMENDMENT, VERSION 3: RATIONALE Protocol BIG 16-05/AFT-27/WO39391 (WO39391)has been amended to modify the IMpassion030: Phase III randomized, open label adjuvant TNBC trial (Alliance/BIG) Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early-stage triple-negative breast cancer. 17. Nussdorfer Platz 8 1190 Vienna, Austria Phone +43 1 408 92 30 info@abcsg. National Comprehensive Cancer 徐兵河 主任医师,教授,博士生导师. Dec 12, 2019 · Roche's Tecentriq is the only anti-PD(L)1 antibody to have won approval in triple negative breast cancer, but the extent to which these checkpoint inhibitors will play a role in this disease remains unclear. [1] Aug 25, 2020 · However, that concern didn’t impact on the selection of paclitaxel in Impassion131, or two other ongoing Impassion trials (Impassion030 and 050) which both employ paclitaxel, along with another dozen or so trials listed in clinicaltrials. IMpassion131 aims to recruit 540 patients with advanced TNBC. 中国医学科学院、北京协和医学院肿瘤医院内科主任 中国抗癌协会乳腺癌专业委员会第七届主任委员 中国抗癌协会肿瘤药物临床研究专业委员会候任主任委员 国家肿瘤质控中心乳腺癌专家委员会主任委员 中国老年医学学会肿瘤分会副会长 北京乳腺病防治学会 肿瘤免疫疗法是人类对抗癌症的新型武器,目前美国制药巨头默沙东是该领域的佼佼者,该公司PD-1肿瘤免疫疗法Keytruda在极其有利可图的肺癌市场已占据了霸主地位,同时也已获批治疗其他多种类型的肿瘤。 虽然三阴性乳腺癌(TNBC)仍然难以治疗,但是有一些临床试验结果非常振奋人心,其包括抗PD-L1抗体,PARP抑制剂和新型的抗体-偶联药物。下面Rossy给大家盘点下,2019年,究竟有哪些新药物,给三阴性乳腺癌患者带来… ABCSG 47 / Impassion030 Studiendetails * Website durchsuchen. Because of the negative hormone receptor and human epidermal growth factor receptor 2 status, therapy is mainly based on chemotherapy with a poor median overall survival in the metastatic setting of ~ 18&nbsp;months. 聚焦2020sabcs,解读阿替利珠单抗最新研究进展。 2020年第43届圣安东尼奥乳腺癌研讨会(sabcs)于12月8-12日以线上形式召开。 AM19-Proceedings-Full ASCO. Seuss Public Library PDF ID e55bcfce chemotherapy in psychiatry revised and enlarged edition pdf Favorite eBook Reading shipping on qualifying offers chemotherapy in psychiatry chemotherapy in psychiatry revised and Researchers eagerly await results from several clinical trials testing immunotherapies in metastatic breast cancer, including A-BRAVE, IMpassion030, and NeoTRIPaPDL1 (Table). 3 From third-generation chemotherapy Nov 20, 2019 · Immunotherapy is emerging as an effective treatment option for metastatic triple-negative breast cancer. "Con inmunoterapia, vamos a trabajar también con otros grupos internacionales como GEICAM, en enfermedad triple negativa en fases iniciales; será el 'IMpassion030' con Atezolizumab en adyuvancia IMpassion030: Multizentrische, randomisierte, offene Phase-III-Studie zum Vergleich von Atezolizumab (Antikörper gegen PD-L1) in Kombination mit einer adjuvanten 早期发现是提高乳腺癌生存率的关键. She has designed, conducted, and reported on many studies in breast cancer and is currently the co-PI for a large, randomized, international phase 3 study exploring adjuvant chemotherapy with or without immune therapy for the treatment of triple negative breast cancer (IMpassion030). What is a clinical trial? Clinical trials are research studies that explore whether a medical strategy, treatment or device is safe and effective for humans. ALEXANDRA (IMpassion030) is a clinical trial partnership between Roche, the Breast International Group (BIG), Alliance Foundation Trials (AFT), Institut Jules Bordet (IJB) and Frontier Science. ALEXANDRA/IMpassion030: A phase 3 study of standard adjuvant chemotherapy with or without atezolizumab in early stage triple negative breast cancer. What will be the role of 1st line IO + chemo combo in few years? AC / T TNBC** (adjuvant): paclitaxel ± Tecentriq IMpassion030 Phase III TNBC (neoadjuvant): nab-paclitaxel ± Tecentriq IMpassion031 Phase III 2021 HER2+ (neoadjuvant): Herceptin + Perjeta + chemo ± Tecentriq IMpassion050 Phase III Ovarian cancer carboplatin + paclitaxel + Avastin ± Tecentriq IMagyn050 Phase III 2020 Roche Studies: IMpassion031 IMpassion030 IMpassion130 Atezo/pla+chemo Atezo/none+chemo Atezo/pla+chemo pCR: pathological complete response; EFS: event-free survival; DFS: disease-free survival; OS: overall survival; PFS: progression-free survival. While both Tecentriq and paclitaxel are approved to treat some types of advanced TNBC, they should not be used together. For all other trials, there is a 4-week delay in processing a trial submitted/resubmitted to the ANZCTR and additional delays for updates of registered trials. budosy Doku-Service und Systemberatung: Clinical Research Associate. Radiothérapie GANEA 3 “Con inmunoterapia”, añade la doctora Carrasco, “vamos a trabajar también con otros grupos internacionales como GEICAM, en enfermedad triple negativa en fases iniciales; será el IMpassion030 con Atezolizumab en adyuvancia y, luego, en colaboración con el grupo alemán (German Breast Group / GBG), los estudios GEPARDOUZE con la misma CA209-025 Eine randomisierte, offene Phase 3 Studie zum Vergleich von Nivolumab (BMS-936558) mit Everolimus bei Patienten mit fortgeschrittenem oder metastasiertem klarzelligem Nierenzellkarzinom, die zuvor eine anti-angiogene Therapie erhalten haben CA209-025 A Randomized, Open-Label, Phase 3 Study of Nivolumab (BMS-936558) vs. Impassion030 Early TNBC Adjuvant Atezolizumab 2300 iDFS Immunotherapy trials in early TNBC. KLINIKUM DER UNIVERSITÄT MÜNCHEN KLINIK UND POLIKLINIK FÜR FRAUENHEILKUNDE UND GEBURTSHILFE DIREKTOR: PROF. Dans ce cas indiquez l'acronyme et le titre de cette nouvelle étude dans la partie commentaire et veillez à indiquer vos coordonnées, nous vous re-contacterons. INTRODUCTION. pdf - Free ebook download as PDF File (. c Joint project with AbbVie. gov. TNBC TNBC incidence Neoadj treated Adjuvant treated 1L drug-treated EU5 US 58k 22k 48k 15k Key readouts and new studies in TNBC and HR+ BC Three ongoing trials for Tecentriq in early TNBC ipatasertib • IPATUNITY130: 1L TNBC/HR+ mBC1 Impassion030 Alexandra. Search Services View List This study will evaluate the efficacy, safety, and pharmacokinetics of adjuvant atezolizumab in combination with paclitaxel, followed by atezolizumab, dose-dense doxorubicin or epirubicin (investigator's choice), and cyclophosphamide, compared with paclitaxel followed by dose-dense doxorubicin or epirubicin (investigator's choice) and cyclophosphamide alone in patients with Stage II-III TNBC TPS1104 Background: Treatment for mTNBC is limited, with chemotherapy the mainstay (bevacizumab is approved in > 80 countries). 0 0 0. Dec 18, 2019 · Dr. ご訪問ありがとうございます。本庶先生のノーベル賞受賞で話題の『免疫チェックポイント阻害剤』話題の「オプジーボ」は、乳癌については、未だ保険適応になっておらずグ… 近日,J Natl Compr Canc Netw杂志(IF=7. Jun 08, 2020 · Triple-negative breast cancer constitutes ~ 15% of all breast cancer subtypes. He is particularly interested in drug and biomarker development in breast cancer. mTNBC has high levels of tumor-infiltrating immune cells, increased PD-L1 expression and high mutation rates that may A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. global alexandra/impassion030 a phase iii, multicenter, randomized, open-label study comparing atezolizumab (anti-pd-l1 IMpassion031 is a global Phase III, double-blind, randomized, multicenter, placebo-controlled study being conducted to evaluate the efficacy and safety of neoadjuvant treatment with nab-paclitaxel → doxorubicin + cyclophosphamide and either atezolizumab or placebo in invasive stage II/III early TNBC. Table. 1 but leaves PD-L2/PD-1 binding intact. You may be eligible to participate in this study if you: Search our services and programs offered by our experts at our hundreds of locations throughout Western New York and the Finger Lakes region. Atezo is an anti–programmed death-ligand 1 (PD-L1) monoclonal antibody that prevents PD-L1 from binding to PD-1 and B7. In this review, we summarize clinical data of immunotherapy in triple-negative breast cancer and comment on future directions in the field. Nussdorfer Platz 8 1190 Wien +43 1 408 92 30. Notable examples recently approved by National Institute for Health and Care Excellence in the UK to guide treatment 転移・再発乳癌に対する全身性の前治療歴のない転移・再発又は局所進行性のホルモン受容体陰性かつHER2陰性乳癌患者を対象に、テセントリク + nab-PTX併用療法の有効性及び安全性をプラセボ + nab-PTX併用療法と比較する。 IMpassion030; Número de Registro NCT03498716; Tipo de Mutación; Patrocinador PRA Health Sciences Hoffmann-La Roche Frontier Science and Technology Research Foundation Inc (FS) Institut Jules Bordet/Clinical Trials Support Unit (IJB/CTSU) Alliance Foundation Trials (AFT) Breast International Group; Etiquetas Cáncer de mama 图5 IMpassion030试验与NSABP B-59试验的研究设计. Appalaches. 中国医学科学院、北京协和医学院肿瘤医院内科主任 中国抗癌协会乳腺癌专业委员会第七届主任委员 中国抗癌协会肿瘤药物临床研究专业委员会候任主任委员 国家肿瘤质控中心乳腺癌专家委员会主任委员 中国老年医学学会肿瘤分会副会长 北京乳腺病防治学会 Zumindest im metastasierten Setting ist dies wohl der Fall und die präsentierten Daten stellen hier wohl einen Wechsel in der Standardbehandlung dar. PDF | Background Up to now, preoperative and postoperative chemotherapies are mainly based on anthracycline and taxane for early breast cancer, however, | Find, read and cite all the research Jun 20, 2019 · And so, the trial that we’re talking about, the IMpassion030 trial, this is a global collaboration between the Alliance Cooperative Group in the United States, the Breast International Group, Genentech, Roche, and it’s going to enroll 2300 patients from around the world. Concretamente, la directora general y científica de GEICAM, Eva Carrasco, ha informado de que su organismo va a llevar a cabo el estudio 'IMPassion030' con atezolizumab en adyuvancia en pacientes Étude de phase III, multicentrique, randomisée, en ouvert, comparant l'atézolizumab (Anticorps Anti-PD-L1) en association à la chimiothérapie adjuvante à base d'anthracycline/taxane versus chimiothérapie seule chez des patients atteins d'un cancer du sein triple négatif opérable » Etude IMPASSION030 - Protocole WO39391 (IMpassion030) Rekrutterer fortsatt Resultater: Desember 2024 *ClinicalTrials. Similarly, 2 large trials are addressing whether the addition of atezolizumab to both neoadjuvant and adjuvant therapy prolongs EFS or invasive DFS: the placebo-controlled NSABP B-59 trial (NCT03281954) of atezolizumab added to neoadjuvant 4-agent chemotherapy followed by 1 year of adjuvant atezolizumab, and the IMpassion030 trial (NCT03498716 ALEXANDRA/IMpassion030 is a global, prospective, randomized, open-label, phase 3 trial currently investigating the efficacy, safety and pharmacokinetic profile of adjuvant atezolizumab plus standard anthracycline/taxane adjuvant chemotherapy versus chemotherapy alone in early stage TNBC. impassion030

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